Citicoline sodium salt is an intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes and also exerts neuroprotective effects.

Product information

CAS Number: 33818-15-4

Molecular Weight: 510.31

Formula: C14H25N4NaO11P2

Synonym:

Cytidine diphosphate-choline sodium

CDP-Choline sodium

Cytidine 5'-diphosphocholine sodium

Chemical Name: 2-(trimethylazaniumyl)ethyl [({[(2R, 3S, 4R, 5R)-5-(4-amino-2-oxo-1, 2-dihydropyrimidin-1-yl)-3, 4-dihydroxyoxolan-2-yl]methoxy}(sodiooxy)phosphoryl)oxy]phosphonate

Smiles: C[N+](C)(C)CCOP([O-])(=O)OP(=O)(O[Na])OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=CC(N)=NC1=O

InChiKey: YWAFNFGRBBBSPD-OCMLZEEQSA-M

InChi: InChI=1S/C14H26N4O11P2.Na/c1-18(2,3)6-7-26-30(22,23)29-31(24,25)27-8-9-11(19)12(20)13(28-9)17-5-4-10(15)16-14(17)21;/h4-5,9,11-13,19-20H,6-8H2,1-3H3,(H3-,15,16,21,22,23,24,25);/q;+1/p-1/t9-,11-,12-,13-;/m1./s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: H2O : ≥ 100 mg/mL (195.96 mM) DMSO : 1 mg/mL (1.96 mM; ultrasonic and warming and heat to 80°C)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703.
2. Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7.

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