Tetranectin Polyclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: BS91330-50, BS91330-100

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P05452(Human) P43025(Mouse)

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB, ICC IF, IHC, IP,

All Applications: WB:1:1,000-1:5,000
ICC:1:50-1:200
IHC:1:50-1:200
IP:1:10-1:50

Background: Tetranectin is a homotrimeric glycoprotein present in plasma and various tissue locations that binds to calcium, heparin, and plasminogen kringle 4. Tetranectin may play a prominent role in tissue remodeling as well as in the regulation of proteolytic processes via its binding and indirect activation of plasminogen. Tetranectin is found in the extracellular matrix (ECM) of certain carcinomas, but is not present in the ECM of normal tissues. Extracellular proteolysis is an important factor in the ability of malignant cells to penetrate normal tissues and metastasize. Decreased plasma tetranectin or increased tetranectin in stroma of cancers correlates with cancer progression and a grim prognosis. Tetranectin may also influence cancer growth by altering activities of plasminogen or the plasminogen fragment, angiostatin which inhibits tumor cell proliferation.

Purification and Purity: ProA affinity purified

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: Tetranectin polyclonal antibody detects endogenous levels of Tetranectin protein.

Bioworld Molecular Weight: 22 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of Tetranectin on rat skin (1) and human skin (2) tissue lysates using anti-Tetranectin antibody at 1/1,000 dilution., ICC staining Tetranectin in HepG2 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS.

Alternative Name: TN, CLEC3B, TNA, C type lectin domain family 3 member B, C-type lectin domain family 3 member B, Clec3b, Plasminogen kringle 4 binding protein, Plasminogen kringle 4-binding protein, TETN, Tetranectin (plasminogen binding protein), Tetranectin, TN, TNA,

Conjugate: Unconjugated

Modification: Unmodified