Norwogonin, isolated from Scutellaria baicalensis Georgi, possesses antiviral activity against Enterovirus 71 (EV71) with an IC50 of 31.83 μg/ml

Product information

CAS Number: 4443-09-8

Molecular Weight: 270.24

Formula: C15H10O5

Chemical Name: 5,7,8-trihydroxy-2-phenyl-4H-chromen-4-one

Smiles: OC1C=C(O)C(O)=C2OC(=CC(=O)C=12)C1C=CC=CC=1

InChiKey: ZFKKRRMUPBBYRS-UHFFFAOYSA-N

InChi: InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Norwogonin (0.4, 2, 10, and 50 μg/mL; 48 hours) inhibits EV71 replication in Vero cells and prevents the cytotoxicity induced by EV71 infection. Norwogonin (50 μg/mL; 48 hours) dramatically decreases viral VP2 protein expression. Norwogonin (50 μg/mL; 48 hours) strongly decreases the expression of EV71 NCR gene at 48 h.

Products are for research use only. Not for human use.