Caspase-3 Polyclonal Antibody Sizes: 50μL, 100μL Catalogue Numbers: RA20669-50, RA20669-100 Citations, Manuals and MSDS Available upon request. Background: caspase 3 (CASP3) Homo sapiens This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008], Condition: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. Storage Instructions: -20°C/1 year Recommended dilutions: IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300 Alternative Names: CASP3; CPP32; Caspase-3; CASP-3; Apopain; Cysteine protease CPP32; CPP-32; Protein Yama; SREBP cleavage activity 1; SCA-1 Applications: IF/ICC; WB; IHC-p; ELISA Species Cross-Reactivity: Human; Mouse; Rat GeneID (Human): 836 Protein MW (KDa): 35 SWISS: P42574 Source: Rabbit Research Use Only