Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL.

Product information

CAS Number: 2383085-86-5

Molecular Weight: 876.07

Formula: C48H57N7O7S

Chemical Name: 4-{2-[(2S)-2-(2-ethylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl}-N-(4-{[(4-hydroxy-4-methylcyclohexyl)methyl]amino}-3-nitrobenzenesulfonyl)-2-{1H-pyrrolo[2,3-b]pyridin-5-yloxy}benzamide

Smiles: CC1(O)CCC(CNC2=CC=C(C=C2[N+]([O-])=O)S(=O)(=O)NC(=O)C2=CC=C(C=C2OC2C=C3C=CNC3=NC=2)N2CCC3(CC(C3)N3CCC[C@H]3C3=CC=CC=C3CC)CC2)CC1

InChiKey: DTVOZSGYTQLYFR-WBEVPWTISA-N

InChi: InChI=1S/C48H57N7O7S/c1-3-33-7-4-5-8-39(33)42-9-6-22-54(42)36-28-48(29-36)19-23-53(24-20-48)35-10-12-40(44(26-35)62-37-25-34-16-21-49-45(34)51-31-37)46(56)52-63(60,61)38-11-13-41(43(27-38)55(58)59)50-30-32-14-17-47(2,57)18-15-32/h4-5,7-8,10-13,16,21,25-27,31-32,36,42,50,57H,3,6,9,14-15,17-20,22-24,28-30H2,1-2H3,(H,49,51)(H,52,56)/t32?,42-,47?/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Bcl-2-IN-2 inhibits mutant Bcl-2-G101V with an IC50 of 1.2 nM. Bcl-2-IN-2 inhibits RS4;11 cellular proliferation with an IC50 of 1.9 nM.

Products are for research use only. Not for human use.