Licochalcone E, a flavonoid compound isolated from Glycyrrhiza inflate, inhibits NF-κB and AP-1 transcriptional activity through the inhibition of AKT and MAPK activation.

Product information

CAS Number: 864232-34-8

Molecular Weight: 338.40

Formula: C21H22O4

Chemical Name: (2E)-3-{4-hydroxy-2-methoxy-5-[(2S)-3-methylbut-3-en-2-yl]phenyl}-1-(4-hydroxyphenyl)prop-2-en-1-one

Smiles: CC(=C)[C@H](C)C1=CC(/C=C/C(=O)C2C=CC(O)=CC=2)=C(C=C1O)OC

InChiKey: SWPKMTGYQGHLJS-RNVIBTMRSA-N

InChi: InChI=1S/C21H22O4/c1-13(2)14(3)18-11-16(21(25-4)12-20(18)24)7-10-19(23)15-5-8-17(22)9-6-15/h5-12,14,22,24H,1H2,2-4H3/b10-7+/t14-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Solubility: DMSO : 50 mg/mL (147.75 mM; Need ultrasonic)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥360 days if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

References:

1. Lee HN, et al. Mechanisms by which licochalcone e exhibits potent anti-inflammatory properties: studies with phorbol ester-treated mouse skin and lipopolysaccharide-stimulated murine macrophages. Int J Mol Sci. 2013 May 24;14(6):10926-43.

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