BCL2 Monoclonal Antibody

Sizes: 50µl, 100µl

Catalogue Numbers: MB9086-50, MB9086-100

Product: Mouse IgG1, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: P10415(Human)

Host: Mouse

Reactivity: Human

Applications: WB, IHC

All Applications: WB:1:500-1:1,000
IHC:1:500-1:1,000

Background: Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release.

Purification and Purity: Peptide affinity purified.

Storage and Stability: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze / thaw cycles.

Specificity: BCL2 monoclonal antibody detects endogenous levels of BCL2 protein.

Bioworld Molecular Weight: 26 kDa

Note: For research use only, not for use in diagnostic procedure.

Extra Notes: Western blot analysis of BCL2 on THP-1 lysate using anti-BCL2 antibody at 1/500 dilution., Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-BCL2 antibody. Counter stained with hematoxylin.

Alternative Name: BCL2, Apoptosis regulator Bcl 2, Apoptosis regulator Bcl-2, Apoptosis regulator Bcl2, AW986256, B cell CLL/lymphoma 2, B cell leukemia/lymphoma 2, Bcl-2, Bcl2, BCL2, C430015F12Rik, D630044D05Rik, D830018M01Rik, Leukemia/lymphoma, B-cell, 2, Oncogene B-cell leukemia 2, PPP1R50, Protein phosphatase 1, regulatory subunit 50,

Immunogen: Synthetic peptide within human BCL2 35-60 aa.

Conjugate: Unconjugated

Modification: Unmodified